Meredith, Cristina, Alex, Jackson and April have all reached their 5th year as residents. In a year that can make or break a surgical career, the residents are tasked with their first-ever solo surgeries, no longer under their attendings' direct supervision in the O.R.
Torn apart by Meredith's well-intentioned but devastatingly harmful interference in Derek's Alzheimer's clinical trial, Meredith and Derek are living apart. Their relationship hangs in the balance, as does the fate of their newly adopted daughter, Zola.
Cristina and Owen's wedded bliss is in jeopardy when they can't agree on whether or not to have a baby. When Cristina becomes unexpectedly pregnant and decides to terminate the pregnancy, Owen is against it, leading to the biggest issue in their relationship thus far. Meanwhile Meredith and Cristina, the best of friends, find themselves at the center of each other's worlds once again, as their marriages are tested.
Leading the 5th year residents is newly-appointed Chief Resident April Kepner. Her position of authority is immediately tested by her skeptical peers.
Love abounds in other places in the hospital, as Bailey's relationship with Nurse Eli continues to grow. Richard Webber focuses on caring for his beloved wife, Adele, who has Alzheimer's disease.
Seattle Grace Hospital is a place where life isn't lived in the black and white, but in the shades of grey.
"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, Kevin McKidd as Owen Hunt, Kim Raver as Teddy Altman, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery and Sarah Drew as April Kepner.
"Grey's Anatomy" was created and is executive produced by Shonda Rhimes ("Private Practice", "Introducing Dorothy Dandridge"). Betsy Beers ("Private Practice", "Casanova"), Mark Gordon ("Saving Private Ryan"), Rob Corn ("Chicago Hope"), Tony Phelan and Joan Rater ("Law& Order: Trial by Jury") are executive producers. "Grey's Anatomy" is an ABC Studios production.