The change-of-pace hour will have a parallel structure in that it will split its time between Meredith at Seattle Grace and Cristina at her new job at the Mayo Clinic.
"Usually, we do one episode a year where it's all Meredith," she [Ellen Pompeo] explains. "And this season, they decided to do Meredith and Cristina to break it up a little bit and just focus on two people. They're individual storylines, but in our own storylines, it's sort of ALL us."
Source: TV Line