Here is the tidbit from TV Guide:
Before signing off on the idea, ABC executives needed some convincing. So series creator Shonda Rhimes recruited Sara, Kevin and Chandra to perform a cabaret-style presentation of favorite songs heard in Grey's early years. The next step: hiring a vocal coach and luring skeptical cast members like Patrick, Ellen Pompeo (Meredith), Sandra Oh (Cristina) and Justin Chambers (Alex) — none known for their musical stylings — to participate in the background chorus. "Everybody had their own reaction," says Sara. "And understandably so. For some, it can be confronting."
Sandra and Patrick Dempsey remained unconvinced because they are the only ones who won't be doing any singing in the episode.